Nature Communications (Feb 2017)

Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging

  • Michael F. Cuccarese,
  • J. Matthew Dubach,
  • Christina Pfirschke,
  • Camilla Engblom,
  • Christopher Garris,
  • Miles A. Miller,
  • Mikael J. Pittet,
  • Ralph Weissleder

DOI
https://doi.org/10.1038/ncomms14293
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 10

Abstract

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Tumour-associated macrophages (TAM) can be used as prognostic indicators in cancer. Here, the authors establish a platform for high-throughput 3D microscopy in murine lung carcinoma that allows to visualize TAMs infiltration throughout the entire lung, response to CSF-1R blockade and nanoparticle drug delivery.