ChemistryOpen
(Mar 2023)
Efficient Synthesis of 3‐Mercaptoindoles via HI‐Promoted Sulfenylation of Indoles with Sodium Sulfinates
Shengnan Sun,
Hexia Ye,
Haibo Liu,
Dr. Yongbiao Guo,
Zhenhua Gao,
Dr. Li Pan,
Dr. Junchen Li,
Prof. Dr. Xiaojing Bi
Affiliations
Shengnan Sun
State Key Laboratory of NBC Protection for Civilian 102205 Beijing China
Hexia Ye
State Key Laboratory of NBC Protection for Civilian 102205 Beijing China
Haibo Liu
State Key Laboratory of NBC Protection for Civilian 102205 Beijing China
Dr. Yongbiao Guo
State Key Laboratory of NBC Protection for Civilian 102205 Beijing China
Zhenhua Gao
State Key Laboratory of NBC Protection for Civilian 102205 Beijing China
Dr. Li Pan
State Key Laboratory of NBC Protection for Civilian 102205 Beijing China
Dr. Junchen Li
State Key Laboratory of NBC Protection for Civilian 102205 Beijing China
Prof. Dr. Xiaojing Bi
State Key Laboratory of NBC Protection for Civilian 102205 Beijing China
DOI
https://doi.org/10.1002/open.202300002
Journal volume & issue
Vol. 12,
no. 3
Abstract
Read online
Abstract A new direct sulfenylation method of indoles by sodium sulfinates and hydroiodic acid was developed giving variety of 3‐sulfenylindoles in high yields under mild conditions without using any catalysts or other additives. In situ‐generated RS‐I species are supposed to be mainly responsible for the key electrophilic alkyl‐ or aryl‐thiolation process.
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