Consciousness-specific dynamic interactions of brain integration and functional diversity

Andrea I. Luppi; Michael M. Craig; Ioannis Pappas; Paola Finoia; Guy B. Williams; Judith Allanson; John D. Pickard; Adrian M. Owen; Lorina Naci; David K. Menon; Emmanuel A. Stamatakis

doi:10.1038/s41467-019-12658-9

Nature Communications (Oct 2019)

Consciousness-specific dynamic interactions of brain integration and functional diversity

Andrea I. Luppi,
Michael M. Craig,
Ioannis Pappas,
Paola Finoia,
Guy B. Williams,
Judith Allanson,
John D. Pickard,
Adrian M. Owen,
Lorina Naci,
David K. Menon,
Emmanuel A. Stamatakis

Affiliations

Andrea I. Luppi: Division of Anaesthesia, School of Clinical Medicine, University of Cambridge, Addenbrooke’s Hospital
Michael M. Craig: Division of Anaesthesia, School of Clinical Medicine, University of Cambridge, Addenbrooke’s Hospital
Ioannis Pappas: Division of Anaesthesia, School of Clinical Medicine, University of Cambridge, Addenbrooke’s Hospital
Paola Finoia: Division of Anaesthesia, School of Clinical Medicine, University of Cambridge, Addenbrooke’s Hospital
Guy B. Williams: Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Addenbrooke’s Hospital
Judith Allanson: Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Addenbrooke’s Hospital
John D. Pickard: Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Addenbrooke’s Hospital
Adrian M. Owen: The Brain and Mind Institute, Western Interdisciplinary Research Building, N6A 5B7 University of Western Ontario
Lorina Naci: Trinity College Institute of Neuroscience, School of Psychology, Lloyd Building, Trinity College Dublin
David K. Menon: Division of Anaesthesia, School of Clinical Medicine, University of Cambridge, Addenbrooke’s Hospital
Emmanuel A. Stamatakis: Division of Anaesthesia, School of Clinical Medicine, University of Cambridge, Addenbrooke’s Hospital

DOI: https://doi.org/10.1038/s41467-019-12658-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

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How do diversity (entropy) and integration of activity across brain regions interact to support consciousness? Here the authors show that anaesthetised individuals and patients with disorders of consciousness exhibit overlapping reductions in both diversity and integration in the brain’s default mode network.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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