Nature Communications (Feb 2023)
Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis
- Younghun Han,
- Jinyoung Byun,
- Catherine Zhu,
- Ryan Sun,
- Julia Y. Roh,
- Heather J. Cordell,
- Hyun-Sung Lee,
- Vikram R. Shaw,
- Sung Wook Kang,
- Javad Razjouyan,
- Matthew A. Cooley,
- Manal M. Hassan,
- Katherine A. Siminovitch,
- Trine Folseraas,
- David Ellinghaus,
- Annika Bergquist,
- Simon M. Rushbrook,
- Andre Franke,
- Tom H. Karlsen,
- Konstantinos N. Lazaridis,
- The International PSC Study Group,
- Katherine A. McGlynn,
- Lewis R. Roberts,
- Christopher I. Amos
Affiliations
- Younghun Han
- Institute for Clinical and Translational Research, Baylor College of Medicine
- Jinyoung Byun
- Institute for Clinical and Translational Research, Baylor College of Medicine
- Catherine Zhu
- Institute for Clinical and Translational Research, Baylor College of Medicine
- Ryan Sun
- Department of Biostatistics, University of Texas, M.D. Anderson Cancer Center
- Julia Y. Roh
- Department of Pharmacy, Ochsner Health
- Heather J. Cordell
- Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University
- Hyun-Sung Lee
- David J. Sugarbaker Division of Thoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine
- Vikram R. Shaw
- Institute for Clinical and Translational Research, Baylor College of Medicine
- Sung Wook Kang
- David J. Sugarbaker Division of Thoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine
- Javad Razjouyan
- VA HSR&D, Center for Innovations in Quality, Effectiveness and Safety, Michael E. DeBakey VA Medical Center
- Matthew A. Cooley
- Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic
- Manal M. Hassan
- Department of Epidemiology, The University of Texas MD Anderson Cancer Center
- Katherine A. Siminovitch
- Departments of Medicine, Immunology and Medical Sciences, University of Toronto
- Trine Folseraas
- Norwegian PSC Research Center, Oslo University Hospital Rikshospitalet
- David Ellinghaus
- Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel
- Annika Bergquist
- Department of Medicine Huddinge, Unit of Gastroenterology and Rheumatology, Karolinska Institutet, Karolinska University Hospital
- Simon M. Rushbrook
- Department of Gastroenterology, Norfolk and Norwich University Hospital
- Andre Franke
- Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel
- Tom H. Karlsen
- Oslo University Hospital Rikshospitalet and University of Oslo
- Konstantinos N. Lazaridis
- Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic
- The International PSC Study Group
- Katherine A. McGlynn
- Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Lewis R. Roberts
- Oslo University Hospital Rikshospitalet and University of Oslo
- Christopher I. Amos
- Institute for Clinical and Translational Research, Baylor College of Medicine
- DOI
- https://doi.org/10.1038/s41467-023-36678-8
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 13
Abstract
The genetic basis of primary sclerosing cholangitis has only been partially uncovered. Here, the authors perform a multitrait genome-wide association study to provide insight into the genetic etiology of primary sclerosing cholangitis risk and possible therapeutic drug targets.
