Emerging Infectious Diseases (Jan 2015)

Oseltamivir-Resistant Influenza A(H1N1)pdm09 Viruses, United States, 2013–14

  • Margaret Okomo-Adhiambo,
  • Alicia Fry,
  • Su Su,
  • Ha T. Nguyen,
  • Anwar Abd Elal,
  • Elizabeth Negron,
  • Julie Hand,
  • Rebecca J. Garten,
  • John Barnes,
  • Xu Xiyan,
  • Julie M. Villanueva,
  • Larisa Gubareva

DOI
https://doi.org/10.3201/eid2101.141006
Journal volume & issue
Vol. 21, no. 1
pp. 136 – 141

Abstract

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We report characteristics of oseltamivir-resistant influenza A(H1N1)pdm09 viruses and patients infected with these viruses in the United States. During 2013–14, fifty-nine (1.2%) of 4,968 analyzed US influenza A(H1N1)pdm09 viruses had the H275Y oseltamivir resistance–conferring neuraminidase substitution. Our results emphasize the need for local surveillance for neuraminidase inhibitor susceptibility among circulating influenza viruses.

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