Nature Communications (Oct 2018)

A comprehensive overview of genomic imprinting in breast and its deregulation in cancer

  • Tine Goovaerts,
  • Sandra Steyaert,
  • Chari A. Vandenbussche,
  • Jeroen Galle,
  • Olivier Thas,
  • Wim Van Criekinge,
  • Tim De Meyer

DOI
https://doi.org/10.1038/s41467-018-06566-7
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

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In growth and development genomic imprinting is important in regulating gene expression. Here, the authors study loss of imprinting (LOI) in cancer, developing a mixture model to detect monoallelically expressed loci without genotyping data - applying this novel methodology to TCGA breast cancer data they find massive deregulation of imprinting.