Nature Communications (Jan 2017)
Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease
- Edmund J. Keliher,
- Yu-Xiang Ye,
- Gregory R. Wojtkiewicz,
- Aaron D. Aguirre,
- Benoit Tricot,
- Max L. Senders,
- Hannah Groenen,
- Francois Fay,
- Carlos Perez-Medina,
- Claudia Calcagno,
- Giuseppe Carlucci,
- Thomas Reiner,
- Yuan Sun,
- Gabriel Courties,
- Yoshiko Iwamoto,
- Hye-Yeong Kim,
- Cuihua Wang,
- John W. Chen,
- Filip K. Swirski,
- Hsiao-Ying Wey,
- Jacob Hooker,
- Zahi A. Fayad,
- Willem J. M. Mulder,
- Ralph Weissleder,
- Matthias Nahrendorf
Affiliations
- Edmund J. Keliher
- Center for Systems Biology and Department of Imaging, Massachusetts General Hospital and Harvard Medical School
- Yu-Xiang Ye
- Center for Systems Biology and Department of Imaging, Massachusetts General Hospital and Harvard Medical School
- Gregory R. Wojtkiewicz
- Center for Systems Biology and Department of Imaging, Massachusetts General Hospital and Harvard Medical School
- Aaron D. Aguirre
- Center for Systems Biology and Department of Imaging, Massachusetts General Hospital and Harvard Medical School
- Benoit Tricot
- Center for Systems Biology and Department of Imaging, Massachusetts General Hospital and Harvard Medical School
- Max L. Senders
- Translational and Molecular Imaging Institute and Department of Radiology, Icahn School of Medicine at Mount Sinai
- Hannah Groenen
- Translational and Molecular Imaging Institute and Department of Radiology, Icahn School of Medicine at Mount Sinai
- Francois Fay
- Translational and Molecular Imaging Institute and Department of Radiology, Icahn School of Medicine at Mount Sinai
- Carlos Perez-Medina
- Translational and Molecular Imaging Institute and Department of Radiology, Icahn School of Medicine at Mount Sinai
- Claudia Calcagno
- Translational and Molecular Imaging Institute and Department of Radiology, Icahn School of Medicine at Mount Sinai
- Giuseppe Carlucci
- Department of Radiology, Memorial Sloan-Kettering Cancer Center
- Thomas Reiner
- Department of Radiology, Memorial Sloan-Kettering Cancer Center
- Yuan Sun
- Center for Systems Biology and Department of Imaging, Massachusetts General Hospital and Harvard Medical School
- Gabriel Courties
- Center for Systems Biology and Department of Imaging, Massachusetts General Hospital and Harvard Medical School
- Yoshiko Iwamoto
- Center for Systems Biology and Department of Imaging, Massachusetts General Hospital and Harvard Medical School
- Hye-Yeong Kim
- Center for Systems Biology and Department of Imaging, Massachusetts General Hospital and Harvard Medical School
- Cuihua Wang
- Center for Systems Biology and Department of Imaging, Massachusetts General Hospital and Harvard Medical School
- John W. Chen
- Center for Systems Biology and Department of Imaging, Massachusetts General Hospital and Harvard Medical School
- Filip K. Swirski
- Center for Systems Biology and Department of Imaging, Massachusetts General Hospital and Harvard Medical School
- Hsiao-Ying Wey
- Department of Imaging, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School
- Jacob Hooker
- Department of Imaging, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School
- Zahi A. Fayad
- Translational and Molecular Imaging Institute and Department of Radiology, Icahn School of Medicine at Mount Sinai
- Willem J. M. Mulder
- Translational and Molecular Imaging Institute and Department of Radiology, Icahn School of Medicine at Mount Sinai
- Ralph Weissleder
- Center for Systems Biology and Department of Imaging, Massachusetts General Hospital and Harvard Medical School
- Matthias Nahrendorf
- Center for Systems Biology and Department of Imaging, Massachusetts General Hospital and Harvard Medical School
- DOI
- https://doi.org/10.1038/ncomms14064
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
In vivo imaging of inflammation is crucial for detection and monitoring of many pathologies and noninvasive macrophage quantification has been suggested as a possible approach. Here Keliher et al. describe novel polyglucose nanoparticle tracers that are rapidly excreted by the kidney and with high affinity for macrophages in atherosclerotic plaques.
