Combined Radiation and Hormonal Therapy for Squamous Cell Carcinoma of the Prostate: A Case Report and Review of the Literature

Abstract

Squamous cell carcinoma (SCC) of the prostate is a rare entity, with a prevalence of 0.6-1% among all prostatic carcinomas. Prostatic SCC has a poor prognosis. Although there are a number of treatment modalities, none of them have promised a long-term survival. Herein, we report a case of SCC coexisting with adenocarcinoma of the prostate treated with a combination of hormonal therapy, leuprolide acetate, and radiotherapy. Twenty-four months after treatment, the patient did not progress into metastatic or end-stage disease with the combination treatment modality. The treatment modalities for SCC are still limited. Comparisons of surgery and radiotherapy, and chemotherapy and hormonal therapy showed that they were all ineffective. Combined radiotherapy and hormone therapy may hold promise for longer survival.

Keywords

• Hormonal therapy
• squamous cell carcinoma of prostate
• radiotherapy