Effects of acute aerobic exercise on circulating sTLR and sRAGE profiles in normal‐ and abnormal‐glucose‐tolerant individuals

Abstract

Abstract BMI‐matched normal‐ (NGT, n = 10, 41 ± 4y, 35.6 ± 3.0 kg/m2) and abnormal‐glucose‐tolerant (AGT, n = 16, 51 ± 3y, 34.3 ± 1.5 kg/m2) participants were evaluated for body composition, metabolic health (oral glucose tolerance test [OGTT]), and VO2max. Participants also completed a treadmill walking test at 65% VO2max for 30 min. Total sRAGE, esRAGE, sTLR2, and sTLR4 were assessed via ELISA, and cRAGE was calculated. AGT exhibited greater (p 0.05) following AE. sTLR4 tended to be 36% lower in AGT than NGT (main effect, p = 0.096) and did not change following AE (p > 0.05). Total sRAGE and isoforms were similar (p > 0.05) between groups and did not change following AE (p > 0.05). sTLR2 was correlated with (p < 0.05) basal BG (r = −0.505) and OGTT AUC (r = −0.687). sTLR4 was correlated with basal BG (p < 0.10, r = −0.374) and OGTT AUC (p < 0.05, r = −0.402). Linear regressions were predictive of sTLRs in the basal state (sTLR2: R2 = 0.641, p = 0.01; sTLR4: R2 = 0.566, p = 0.037) and after acute exercise state (sTLR2: R2 = 0.681, p = 0.004, sTLR4: R2 = 0.568, p = 0.036).These findings show circulating sTLR profiles are disrupted in AGT and acute AE minimally modulates their levels.

Keywords

• diabetes
• exercise
• inflammation
• metabolic disease
• sRAGE
• sTLR