Spectrum extended betalactamases prevalence in Escherichia coli, Klebsiella pneumoniae and Klebsiella oxytoca in Hospital Occidente de Kennedy. Level III, Bogotá

Abstract

The objective is estimate the prevalencia forEscherichia coli, Klebsiella pneumoniae, and Klebsiellaoxytoca producers of Beta-lactamasasspectrum extended in the Hospital Occidente ofKennedy Level III. Bogotá. Methodology: They were analyzed in the Hospital West of Kennedy duringthe period understood among November 20 fromthe 2002 to the 30 September of the 2003, 3.574isolates in which 897 stumps of Klebsiellapneumoniae were identified, Klebsiella oxytoca,and Escherichia coli by means of panels ofmicrodilución of the system of MicroScan DriedGram Negative like test of Screening for germidentification and susceptibility to Beta-lactamasasof extended spectrum: Then one carries out testconfirmatoria with system panels MicroScan DriedESBL confirmation recommended for their use byNational Committee for Clinical LaboratoryStandards (NCCLS). Evaluating the concentrationminimum inhibitory for ceftazidima and alonecefotaxima and in combination with sourclavulanico. Results: The results showed a combinedprevalencia of germs producing Beta-lactamasas similarto 18.6% (interval of trust of 95%: 16.2%-21.4%). The prevalencia for Escherichia coli was of9.5%, Klebsiella pneumoniae 43.5%, and Klebsiellaoxytoca 10.3%. The bacterial but high resistanceindexes corresponded to ceftriaxona andceftazidima. Conclusion: The study demonstrates ahigh prevalencia of Beta-lactamasas of spectrum extendedin Gram-negative germs, probably for theexcessive use of antibiotics Beta-lactamicos of widespectrum. She also stands out the importance of thedetection with tests of susceptibility andconfirmation like support for the setting-up of controlmeasures and of epidemic surveillance with thepurpose of reducing indexes of emergent bacterialresistance.

Keywords

• Beta-lactamases
• Gram-negativeBacteri
• prevalence