Hypoglycemic and Hypolipidemic Potential of Ginger-Thyme Combined Extract in Sucrose-Induced Hyperglycemic Rates

Abstract

The current study was designed to investigate the in vivo action of ginger-thyme combined crude extract on hyperglycemia and obesity-related measurements in sucrose-induced chronic hyperglycemia experimental model in albino male rats. Twenty-five male albino rats were divided into five groups (n = 5 for each); the first group was regarded as control, while the second group was the model which consists of high sucrose fed (50% sucrose in water) and other three groups were rats which treated with three different doses of ginger-thyme combination extract (125 mg/kg, 250 mg/kg, and 500 mg/kg). Animals were received one dose/day using oral stomach gavage for 8 weeks. Blood samples were collected for quantitative determination of glucose levels, oral glucose tolerance tests, serum insulin, glycohemoglobin (hemoglobin A1c), and various other laboratory analyses such as lipid profiles, in addition to water intake and body weight throughout the study. Significant reduction of blood glucose levels was occurred in all plant combination extract doses compared to sucrose diet rat model group, especially the medium dose 250 mg/kg which found to be the best one. Serum insulin was reduced in the model group compared to control and treatment groups, while it was increased in all extract treating groups compared to the model group.

Keywords

• hyperglycemia;
• ginger;
• thyme;
• rats