AB0 Hemolytic Disease of the Newborn Development in the Child with АВ (IV) Blood Group from the Mother with 0 (I) Blood Group: Clinical Case

Abstract

Background. Hemolytic disease of the newborn due to AB0 incompatibility typically develops when mother has 0 (I) blood group and prenatal child has А (II) or B (III). Mother’s antibodies аand рhave immune interaction with the child’s antigens A or B in such situation. It became possible for woman with 0 (I) group to carry of the child with AB (IV) group due to the use of donor ovum for in vitro fertilization. Naturally it is impossible. Clinical Case Description. Hemolytic disease of the newborn development in the child with АВ(IV) Blood Group from the Mother with 0 (I) Blood Group is demonstrated. It was the child of the second pregnancy resulting from in vitro fertilization of donor ovum with intracytoplasmic sperm injection and further tubal embryo transfer. The disease was manifested with icteric and anemia syndromes. Hyperbilirubinemia presented from birth, maximum level was on the 5th day of life. The treatment included phototherapy and immunoglobulin intravenous injections. The child's condition was stabilized by the 6th day. Conclusion. The hemolytic disease of the newborn development is possible when the woman with 0 (I) blood group is carrying the fetus with AB (IV) group especially when we are using donor ovum for in vitro fertilization without taking into account the blood group of the donor. It must be considered during preimplantation genetic testing, selection and tubal embryo transfer.

Keywords

• hemolytic disease of the newborn
• abo incompatibility
• reproductive technologies
• donor ovum
• in vitro fertilization