Objective: To analyze the possible features of the blood lipid parameters of women in pre-retirement and retirement age. Materials and methods. We used materials of the two major international projects – «MONICA» and «HAPIEE». According to the protocol of these projects a representative sample of the Novosibirsk population have been surveyed. The analysis included data of 6092 women aged 45–64 years. Results. Levels of TC, nonHDL, LDL in women aged 45–54 years were slightly lower (an average – 10 %) than in the 55–64 years, but the frequency of hypercholesterolemia of LDL was high. Similar characteristics were obtained for the values of the so-called «atherogenic coefficient». Conclusion. «Pro-atherogenic» potential of blood lipid profile in women in pre-retirement and the retirement age is significant. In this connection, it is advisable to wider use lipid-lowering medicaments for women 45–54 years in order to reduce the risk of cardiovascular morbidity and mortality.