Comparison of in vivo antibacterial and antithrombotic activities of two types of pulmonary artery catheters in pig

Abstract

Abstract Background During pulmonary artery catheter (PAC) implantation, inaccurate measurements of hemodynamic parameters due to infection or thrombosis of PAC can result in severe complications. Method In order to develop a new PAC material, we evaluated the antibacterial and antithrombotic activities of the two types of PAC (Swan Ganz catheter and prototype catheter) in 14 pigs. Results In the 3-day group, bacterial infection rate was not different between the two types of PAC. In the 7-day group, bacterial infection rate of the prototype catheter was twice as elevated as that of the Swan-Ganz catheter. In the 3-day group, thrombus formation rate of the prototype catheter was twice as elevated as that of the Swan-Ganz catheter. In the 7-day group, thrombus formation rate was the same for the two types of PAC. Conclusion Here, we report an experimental pig model that confirms differences in antibacterial and antithrombotic activities.

Keywords

• Pulmonary artery catheter
• Infection
• Thrombosis
• Pig