Nature Communications (Oct 2016)

Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle

  • L. Fusi,
  • E. Brunello,
  • Z. Yan,
  • M. Irving

DOI
https://doi.org/10.1038/ncomms13281
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 9

Abstract

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Recent data suggest that muscle contraction is regulated by thick filament mechano-sensing in addition to the well-known thin filament-mediated calcium signalling pathway. Here the authors provide direct evidence that myosin activation in skeletal muscle is controlled by thick filament stress independently of calcium.