The dynamics of humoral componenet of immune system` parameters and the amount of circulating immune complexes under conditions of experimental acute lung injury

Abstract

In the response to the simulation of acute lung injury up to 24 hours it was observed a significant increase of the amount of immunoglobulins A, M, G in blood serum. Up to 72 hours their amount continued to reduce, however, it didn’t reach control level. Under these conditions, in parallel with the increasing of the concentration of immunoglobulins in blood serum, the amount of circulating immune complexes increases with the achievement of maximum level after 24 hours of experiment and with a subsequent decrease to 72 hours, which significantly exceeds control level.

Keywords

• acute lung injury, humoral immunity, circulating immune complexes