Reversible Valproate Hepatotoxicity and Associated Mitochondrial Disease

Abstract

A 2-year-old boy with seizures complicated by reversible valproate-induced hepatic failure was subsequently found to have mitochondrial polymerase g gene (POLG1) mutations typical of Alpers-Huttenlocher disease, in a study at Newcastle University, UK.

Keywords

• hepatotoxicity
• mitochondrial
• alpers-huttenlocher syndrome