Research progress on the determination of free-base nicotine in tobacco and tobacco products

Abstract

The research progress on determination of free-base nicotine in tobacco and tobacco products in the past 30 years was reviewed and discussed, including solvent extraction method, headspace solid-phase microextraction method, 1H NMR, Henderson-Hasselbalch method and spectroscopy method, etc. Advantages and limitations of each method were summarized and discussed and the development in this field was prospected.

Keywords

• free-base nicotine
• solvent extraction method
• headspace solid-phase microextraction method
• 1h nmr
• henderson-hasselbalch method
• spectroscopy method