Class IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription

Yongchuan Zhu; Min Huang; Eric Bushong; Sebastien Phan; Marco Uytiepo; Elizabeth Beutter; Daniel Boemer; Kristin Tsui; Mark Ellisman; Anton Maximov

doi:10.1038/s41467-019-11409-0

Nature Communications (Aug 2019)

Class IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription

Yongchuan Zhu,
Min Huang,
Eric Bushong,
Sebastien Phan,
Marco Uytiepo,
Elizabeth Beutter,
Daniel Boemer,
Kristin Tsui,
Mark Ellisman,
Anton Maximov

Affiliations

Yongchuan Zhu: Department of Neuroscience, The Scripps Research Institute
Min Huang: Department of Neuroscience, The Scripps Research Institute
Eric Bushong: National Center for Microscopy and Imaging Research, University of California
Sebastien Phan: National Center for Microscopy and Imaging Research, University of California
Marco Uytiepo: Department of Neuroscience, The Scripps Research Institute
Elizabeth Beutter: Department of Neuroscience, The Scripps Research Institute
Daniel Boemer: Department of Neuroscience, The Scripps Research Institute
Kristin Tsui: Department of Neuroscience, The Scripps Research Institute
Mark Ellisman: National Center for Microscopy and Imaging Research, University of California
Anton Maximov: Department of Neuroscience, The Scripps Research Institute

DOI: https://doi.org/10.1038/s41467-019-11409-0
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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The molecular mechanisms of memory storage remain poorly understood. In this study, authors describe a new mechanism that regulates the cellular patterns of early response gene signaling during learning via the recruitment of two functionally redundant nuclear repressors, class IIa histone deacetylases (HDACs) 4 and 5

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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