eJHaem (May 2021)

Volunteer unrelated donor cell‐derived acute myeloid leukemia with RUNX1‐RUNX1T1

  • Shinya Hagiwara,
  • Shigeru Kusumoto,
  • Asahi Ito,
  • Ayako Masaki,
  • Kazuhide Shiraga,
  • Takuto Tachita,
  • Kentaro Hirade,
  • Kana Oiwa,
  • Tomotaka Suzuki,
  • Shiori Kinoshita,
  • Masaki Ri,
  • Yasuhiko Ito,
  • Hirokazu Komatsu,
  • Hiroshi Inagaki,
  • Shinsuke Iida

DOI
https://doi.org/10.1002/jha2.169
Journal volume & issue
Vol. 2, no. 2
pp. 285 – 290

Abstract

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Abstract A 15‐year‐old male was diagnosed with acute myeloid leukemia with t(6;9)(p23;q34), a chimeric DEK‐NUP214 fusion gene. He underwent allogeneic bone marrow transplantation (allo‐BMT) from an unrelated volunteer donor at first molecular remission. Approximately 5 years after allo‐BMT, multiple bone marrow aspirations showed increased blasts to 63%, which were positive for myeloperoxidase, CD13, CD33, CD56, and CD34. Surprisingly, t(8;21)(q22;q22.1), a chimeric RUNX1‐RUNX1T1 (not DEK‐NUP214) fusion gene, was detected with full donor chimerism. To our best knowledge, this is the first case of a volunteer unrelated donor cell‐derived acute myeloid leukemia harboring a chimeric RUNX1‐RUNX1T1 fusion gene.

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