Palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides

Abstract

An efficient palladium-catalyzed Heck-type reaction of secondary trifluoromethylated alkyl bromides has been developed. The reaction proceeds under mild reaction conditions with high efficiency and excellent functional group tolerance, even towards formyl and hydroxy groups. Preliminary mechanistic studies reveal that a secondary trifluoromethylated alkyl radical is involved in the reaction.

Keywords

• alkenes
• cross-coupling
• Heck-type reaction
• palladium
• secondary trifluoromethylated alkyl bromides