Nature Communications (Oct 2018)

A distinct isoform of ZNF207 controls self-renewal and pluripotency of human embryonic stem cells

  • Fang Fang,
  • Ninuo Xia,
  • Benjamin Angulo,
  • Joseph Carey,
  • Zackery Cady,
  • Jens Durruthy-Durruthy,
  • Theo Bennett,
  • Vittorio Sebastiano,
  • Renee A. Reijo Pera

DOI
https://doi.org/10.1038/s41467-018-06908-5
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 14

Abstract

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Self-renewal and pluripotency of human embryonic stem cells (hESCs) depends upon the function of the transcription factor OCT4. Here, the authors identified proteins associated with the OCT4 enhancer, notably ZNF207 that maintains both pluripotency and differentiation towards ectoderm through isoform switching.