Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer

Xiaoding Hu; Emilly S. Villodre; Richard Larson; Omar M. Rahal; Xiaoping Wang; Yun Gong; Juhee Song; Savitri Krishnamurthy; Naoto T. Ueno; Debu Tripathy; Wendy A. Woodward; Bisrat G. Debeb

doi:10.1038/s42003-020-01590-0

Communications Biology (Jan 2021)

Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer

Xiaoding Hu,
Emilly S. Villodre,
Richard Larson,
Omar M. Rahal,
Xiaoping Wang,
Yun Gong,
Juhee Song,
Savitri Krishnamurthy,
Naoto T. Ueno,
Debu Tripathy,
Wendy A. Woodward,
Bisrat G. Debeb

Affiliations

Xiaoding Hu: Department of Breast Medical Oncology, the University of Texas MD Anderson Cancer Center
Emilly S. Villodre: Department of Breast Medical Oncology, the University of Texas MD Anderson Cancer Center
Richard Larson: Morgan Welch Inflammatory Breast Cancer Clinic and Research Program, the University of Texas MD Anderson Cancer Center
Omar M. Rahal: Morgan Welch Inflammatory Breast Cancer Clinic and Research Program, the University of Texas MD Anderson Cancer Center
Xiaoping Wang: Department of Breast Medical Oncology, the University of Texas MD Anderson Cancer Center
Yun Gong: Morgan Welch Inflammatory Breast Cancer Clinic and Research Program, the University of Texas MD Anderson Cancer Center
Juhee Song: Department of Biostatistics, the University of Texas MD Anderson Cancer Center
Savitri Krishnamurthy: Morgan Welch Inflammatory Breast Cancer Clinic and Research Program, the University of Texas MD Anderson Cancer Center
Naoto T. Ueno: Department of Breast Medical Oncology, the University of Texas MD Anderson Cancer Center
Debu Tripathy: Department of Breast Medical Oncology, the University of Texas MD Anderson Cancer Center
Wendy A. Woodward: Morgan Welch Inflammatory Breast Cancer Clinic and Research Program, the University of Texas MD Anderson Cancer Center
Bisrat G. Debeb: Department of Breast Medical Oncology, the University of Texas MD Anderson Cancer Center

DOI: https://doi.org/10.1038/s42003-020-01590-0
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 14

Abstract

Read online

Xiaoding Hu et al. find that expression of the proteoglycan decorin is decreased in patients with inflammatory breast cancer compared to normal breast tissue and some other types of breast cancer. They demonstrate that decorin acts as a tumor suppressor in cancer cells and human xenograft mouse models by destabilizing the E-cadherin-EGFR signaling axis, and their findings suggest potential therapeutic strategies for this aggressive breast cancer.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal