Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Cellular and Molecular Biology Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
Sunny Shin
Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Cellular and Molecular Biology Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA
Igor E. Brodsky
Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA; Cellular and Molecular Biology Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA; Corresponding author
Immune responses must be tightly regulated in order to avoid excessive inflammation. In this issue of Cell Reports, Bambouskova et al. (2021) demonstrate that itaconate and iNOS collaborate to tolerize the NLRP3 inflammasome, thereby limiting cytokine secretion and cell death.
