Molecular Neurodegeneration (Mar 2024)
HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases
- Anna Calliari,
- Lillian M. Daughrity,
- Ellen A. Albagli,
- Paula Castellanos Otero,
- Mei Yue,
- Karen Jansen-West,
- Naeyma N. Islam,
- Thomas Caulfield,
- Bailey Rawlinson,
- Michael DeTure,
- Casey Cook,
- Neill R. Graff-Radford,
- Gregory S. Day,
- Bradley F. Boeve,
- David S. Knopman,
- Ronald C. Petersen,
- Keith A. Josephs,
- Björn Oskarsson,
- Aaron D. Gitler,
- Dennis W. Dickson,
- Tania F. Gendron,
- Mercedes Prudencio,
- Michael E. Ward,
- Yong-Jie Zhang,
- Leonard Petrucelli
Affiliations
- Anna Calliari
- Department of Neuroscience, Mayo Clinic
- Lillian M. Daughrity
- Department of Neuroscience, Mayo Clinic
- Ellen A. Albagli
- Department of Neuroscience, Mayo Clinic
- Paula Castellanos Otero
- Department of Neuroscience, Mayo Clinic
- Mei Yue
- Department of Neuroscience, Mayo Clinic
- Karen Jansen-West
- Department of Neuroscience, Mayo Clinic
- Naeyma N. Islam
- Department of Neuroscience, Mayo Clinic
- Thomas Caulfield
- Department of Neuroscience, Mayo Clinic
- Bailey Rawlinson
- Department of Neuroscience, Mayo Clinic
- Michael DeTure
- Department of Neuroscience, Mayo Clinic
- Casey Cook
- Department of Neuroscience, Mayo Clinic
- Neill R. Graff-Radford
- Department of Neurology, Mayo Clinic
- Gregory S. Day
- Department of Neurology, Mayo Clinic
- Bradley F. Boeve
- Department of Neurology, Mayo Clinic
- David S. Knopman
- Department of Neurology, Mayo Clinic
- Ronald C. Petersen
- Department of Neurology, Mayo Clinic
- Keith A. Josephs
- Department of Neurology, Mayo Clinic
- Björn Oskarsson
- Department of Neurology, Mayo Clinic
- Aaron D. Gitler
- Department of Genetics, Stanford University School of Medicine
- Dennis W. Dickson
- Department of Neuroscience, Mayo Clinic
- Tania F. Gendron
- Department of Neuroscience, Mayo Clinic
- Mercedes Prudencio
- Department of Neuroscience, Mayo Clinic
- Michael E. Ward
- National Institute of Neurological Disorders and Stroke, National Institutes of Health
- Yong-Jie Zhang
- Department of Neuroscience, Mayo Clinic
- Leonard Petrucelli
- Department of Neuroscience, Mayo Clinic
- DOI
- https://doi.org/10.1186/s13024-024-00718-8
- Journal volume & issue
-
Vol. 19,
no. 1
pp. 1 – 5
Abstract
Abstract This letter demonstrates the potential of novel cryptic proteins resulting from TAR DNA-binding protein 43 (TDP-43) dysfunction as markers of TDP-43 pathology in neurodegenerative diseases.
