Communications Biology (Mar 2021)
Amadori rearrangement products as potential biomarkers for inborn errors of amino-acid metabolism
- Rianne E. van Outersterp,
- Sam J. Moons,
- Udo F. H. Engelke,
- Herman Bentlage,
- Tessa M. A. Peters,
- Arno van Rooij,
- Marleen C. D. G. Huigen,
- Siebolt de Boer,
- Ed van der Heeft,
- Leo A. J. Kluijtmans,
- Clara D. M. van Karnebeek,
- Ron A. Wevers,
- Giel Berden,
- Jos Oomens,
- Thomas J. Boltje,
- Karlien L. M. Coene,
- Jonathan Martens
Affiliations
- Rianne E. van Outersterp
- Radboud University, Institute for Molecules and Materials, FELIX Laboratory, Toernooiveld 7
- Sam J. Moons
- Radboud University, Institute for Molecules and Materials, Synthetic Organic Chemistry
- Udo F. H. Engelke
- Department of Laboratory Medicine, Translational Metabolic Laboratory, Radboud University Medical Center
- Herman Bentlage
- Radboud University, Institute for Molecules and Materials, FELIX Laboratory, Toernooiveld 7
- Tessa M. A. Peters
- Department of Laboratory Medicine, Translational Metabolic Laboratory, Radboud University Medical Center
- Arno van Rooij
- Department of Laboratory Medicine, Translational Metabolic Laboratory, Radboud University Medical Center
- Marleen C. D. G. Huigen
- Department of Laboratory Medicine, Translational Metabolic Laboratory, Radboud University Medical Center
- Siebolt de Boer
- Department of Laboratory Medicine, Translational Metabolic Laboratory, Radboud University Medical Center
- Ed van der Heeft
- Department of Laboratory Medicine, Translational Metabolic Laboratory, Radboud University Medical Center
- Leo A. J. Kluijtmans
- Department of Laboratory Medicine, Translational Metabolic Laboratory, Radboud University Medical Center
- Clara D. M. van Karnebeek
- Department of Pediatrics, Radboud Center for Mitochondrial Medicine, Radboud University Medical Center
- Ron A. Wevers
- Department of Laboratory Medicine, Translational Metabolic Laboratory, Radboud University Medical Center
- Giel Berden
- Radboud University, Institute for Molecules and Materials, FELIX Laboratory, Toernooiveld 7
- Jos Oomens
- Radboud University, Institute for Molecules and Materials, FELIX Laboratory, Toernooiveld 7
- Thomas J. Boltje
- Radboud University, Institute for Molecules and Materials, Synthetic Organic Chemistry
- Karlien L. M. Coene
- Department of Laboratory Medicine, Translational Metabolic Laboratory, Radboud University Medical Center
- Jonathan Martens
- Radboud University, Institute for Molecules and Materials, FELIX Laboratory, Toernooiveld 7
- DOI
- https://doi.org/10.1038/s42003-021-01909-5
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 8
Abstract
Rianne van Outersterp et al. combine mass spectrometry, NMR, and infrared ion spectroscopy to identify amino acid-hexose conjugates in the blood plasma from patients with metabolic disorders such as phenylketonuria (PKU). These conjugates, or Amadori rearrangement products, are generally not detectable in blood samples from unaffected individuals, and may therefore represent disease biomarkers.
