THE NEUROLOGICAL DISORDERS ASSOCIATED WITH THE ANTIRO/SS-A AND ANTI-LA/SS-B ANTIBODIES: CASE PRESENTATIONS WITH THE LITERATURE REVIEW

Abstract

Over the recent years, a number of publications on the central nervous system (CNS) damages associated with anti-Ro/SS-A and anti-La/ SS-B antibodies has increased, which can signify an increase in the incidence of neuroimmunopathological conditions. Two cases with isolated central nervous system (CNS) impairment and anti-Ro/SS-A and anti-La/SS-B antinuclear antibodies are discussed in the article. In the first case, the CNS impairment with increased rates of anti-Ro/SS-A and anti-La/SS-B antibodies preceded the clinical manifestations and pathomorphological signs corresponding to the diagnostic criteria of Sjogren’s syndrome (SS). In the second case, the paraneoplastic CNS disorder was associated with an increase in the rate of such antibodies and was followed by the oncological process disseminaton. The described studies demonstrate possible heterogeneity of neurologic manifestations of immunopathologic processes. Further research is needed for the immunological targets of anti-Ro/SS-A and anti-La/SS-B antibodies, as well as for the pathophysiological mechanisms of associated neurological disorders.

Keywords

• anti-ro/ss-a
• anti-la/ss-b
• sjogren’s syndrome
• cerebral vasculitis