mBio
(Jun 2021)
Inhibitory Concentrations of Ciprofloxacin Induce an Adaptive Response Promoting the Intracellular Survival of Salmonella enterica Serovar Typhimurium
Sushmita Sridhar,
Sally Forrest,
Derek Pickard,
Claire Cormie,
Emily A. Lees,
Nicholas R. Thomson,
Gordon Dougan,
Stephen Baker
Affiliations
Sushmita Sridhar
ORCiD Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
Sally Forrest
Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
Derek Pickard
Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
Claire Cormie
Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
Emily A. Lees
Department of Paediatrics, University of Oxford, Oxford, United Kingdom
Nicholas R. Thomson
Wellcome Sanger Institute, Hinxton, United Kingdom
Gordon Dougan
Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
Stephen Baker
ORCiD Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
DOI
https://doi.org/10.1128/mBio.01093-21
Journal volume & issue
Vol. 12,
no. 3
Abstract
Read online
Antimicrobial resistance is a critical concern in global health. In particular, there is rising resistance to fluoroquinolones, such as ciprofloxacin, a first-line antimicrobial for many Gram-negative pathogens.
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