Nature Communications (Dec 2019)
Eliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles
- Xiaodong Xie,
- Huifang Nie,
- Yu Zhou,
- Shu Lian,
- Hao Mei,
- Yusheng Lu,
- Haiyan Dong,
- Fengqiao Li,
- Tao Li,
- Bifei Li,
- Jie Wang,
- Min Lin,
- Chaihung Wang,
- Jingwei Shao,
- Yu Gao,
- Jianming Chen,
- Fangwei Xie,
- Lee Jia
Affiliations
- Xiaodong Xie
- Cancer Metastasis Alert and Prevention Center, College of Chemistry; Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Minjiang University
- Huifang Nie
- Cancer Metastasis Alert and Prevention Center, College of Chemistry; Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Minjiang University
- Yu Zhou
- Cancer Metastasis Alert and Prevention Center, College of Chemistry; Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Minjiang University
- Shu Lian
- Cancer Metastasis Alert and Prevention Center, College of Chemistry; Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Minjiang University
- Hao Mei
- Cancer Metastasis Alert and Prevention Center, College of Chemistry; Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Minjiang University
- Yusheng Lu
- Institute of Oceanography, Minjiang University
- Haiyan Dong
- Cancer Metastasis Alert and Prevention Center, College of Chemistry; Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Minjiang University
- Fengqiao Li
- Cancer Metastasis Alert and Prevention Center, College of Chemistry; Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Minjiang University
- Tao Li
- Cancer Metastasis Alert and Prevention Center, College of Chemistry; Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Minjiang University
- Bifei Li
- Cancer Metastasis Alert and Prevention Center, College of Chemistry; Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Minjiang University
- Jie Wang
- Cancer Metastasis Alert and Prevention Center, College of Chemistry; Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Minjiang University
- Min Lin
- Cancer Metastasis Alert and Prevention Center, College of Chemistry; Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Minjiang University
- Chaihung Wang
- Cancer Metastasis Alert and Prevention Center, College of Chemistry; Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Minjiang University
- Jingwei Shao
- Cancer Metastasis Alert and Prevention Center, College of Chemistry; Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Minjiang University
- Yu Gao
- Cancer Metastasis Alert and Prevention Center, College of Chemistry; Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Minjiang University
- Jianming Chen
- Institute of Oceanography, Minjiang University
- Fangwei Xie
- Department of Oncology, Fuzhou General Hospital
- Lee Jia
- Cancer Metastasis Alert and Prevention Center, College of Chemistry; Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Minjiang University
- DOI
- https://doi.org/10.1038/s41467-019-13316-w
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Oncogenic exosomes can circulate in the blood, but their selective removal has not been possible. Here the authors show that aptamer-functionalised mesoporous silica nanoparticles can find to a specific population of circulating exosomes and eliminate them via the hepatobiliary route.
