THE ROLE OF GENE POLYMORPHISMS ETIOPATHOGENETIC IN SCHIZOPHRENIA

Abstract

In a review article summarizes the role of polymorphisms in genes etiopathogenetic schizophrenia. A convincing relationship of polymorphic variants 5-HTR2A gene and gene DRD2 with clinical heterogeneity of schizophrenia.Found that genotype A2A2 in case 5-HTR2A gene and genotype of the DRD2 gene to A2A2, and their combination is significantly more common in patients with the chronic form of schizophrenia characterized by a significant degree of negative symptoms, formerly home and hereditary burdenedness on schizophrenia. Is set to increase in relative risk for schizophrenia different severity in the presence of genotype 5-HTR2A A2A2 compared to genotype A1A1.In addition, a relationship of genotype 5-HTR2A A2A2 family form of schizophrenia. An association of DD genotype and allele D angiotenzin converting enzyme gene with schizophrenia in men. This tended to increase the frequency of the genotype (DD) in patients with schizophrenia with duration of more than 15 years. Thus, topical is the study of genetic markers of risk for schizophrenia and their use of multivariate analysis of the etiopathogenesis of the disease.

Keywords

• schizophrenia
• genes polymorphism genotypes