Design, Synthesis and Structure-Activity Relationship of Novel Pinacolone Sulfonamide Derivatives against <i>Botrytis cinerea</i> as Potent Antifungal Agents
Chaojie Liu,
Xiaofang Xiang,
Ying Wan,
Jia Yang,
Yufei Li,
Xinchen Zhang,
Zhiqiu Qi,
Lu He,
Wei Liu,
Xinghai Li
Affiliations
Chaojie Liu
Department of Pesticide Science, Plant Protection College, Shenyang Agricultural University, Shenyang 110866, China
Xiaofang Xiang
Department of Pesticide Science, Plant Protection College, Shenyang Agricultural University, Shenyang 110866, China
Ying Wan
Department of Pesticide Science, Plant Protection College, Shenyang Agricultural University, Shenyang 110866, China
Jia Yang
Department of Pesticide Science, Plant Protection College, Shenyang Agricultural University, Shenyang 110866, China
Yufei Li
Department of Pesticide Science, Plant Protection College, Shenyang Agricultural University, Shenyang 110866, China
Xinchen Zhang
Department of Pesticide Science, Plant Protection College, Shenyang Agricultural University, Shenyang 110866, China
Zhiqiu Qi
Department of Pesticide Science, Plant Protection College, Shenyang Agricultural University, Shenyang 110866, China
Lu He
Department of Pesticide Science, Plant Protection College, Shenyang Agricultural University, Shenyang 110866, China
Wei Liu
Department of Pesticide Science, Plant Protection College, Shenyang Agricultural University, Shenyang 110866, China
Xinghai Li
Department of Pesticide Science, Plant Protection College, Shenyang Agricultural University, Shenyang 110866, China
To develop new fungicides with high efficiency, 46 novel sulfonamide derivatives were designed and synthesized by introducing pinacolone fragment into chesulfamide which was used as lead compound. All compounds were characterized by 1H NMR, 13C NMR, and MS spectra, and the structure of compound P-27 was also confirmed by X-ray single crystal diffraction. It was found that a variety of compounds present excellent inhibitory effect against Botrytis cinerea. The inhibition rates of P-29 on tomato and strawberry were 90.24% (200 mg/L) and 100% (400 mg/L) in vivo respectively, which were better than the lead compound chesulfamide (59.23% on tomato seedlings and 29.63% on strawberries).
