Clinical and Translational Allergy (Oct 2012)

A positive serum basophil histamine release assay is a marker for ciclosporin-responsiveness in patients with chronic spontaneous urticaria

  • Iqbal Kamran,
  • Bhargava Kapil,
  • Skov Per,
  • Falkencrone Sidsel,
  • Grattan Clive EH

DOI
https://doi.org/10.1186/2045-7022-2-19
Journal volume & issue
Vol. 2, no. 1
p. 19

Abstract

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Abstract The electronic records of 398 patients with chronic spontaneous urticaria (CSU) who had had a serum basophil histamine release assay (BHRA) performed as a marker of functional autoantibodies were audited. The BHRA was positive in 105 patients (26.4%). Fifty eight were treated with ciclosporin because they were H1 anti-histamine unresponsive. CSU patients with a positive BHRA were more likely to respond clinically (P

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