AIDS Research and Therapy (May 2025)

Effectiveness of dolutegravir-based treatment among HIV/AIDS patients in Nkembo Outpatient Treatment Center, Gabon

  • Christian Mangala,
  • Rolf Moukanda-Ifoundou,
  • Denis Maulot-Bangola,
  • Alain Moutsinga,
  • Christian Mombo-Maganga,
  • Serge Christian Okolongo-Mayani,
  • Brice Ongali,
  • Guy Joseph Lemamy,
  • Rachyda Massolou-Outata

DOI
https://doi.org/10.1186/s12981-025-00744-6
Journal volume & issue
Vol. 22, no. 1
pp. 1 – 5

Abstract

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Abstract Background HIV/AIDS therapy continues to make an enormous contribution to improving the well-being of HIV/AIDS patients globally. In Gabon, dolutegravir is administered to HIV/AIDS patients from first-line treatment. This study aimed to determine the effectiveness rate of dolutegravir-based treatment among HIV/AIDS patients. Methods A retrospective observational study was conducted among HIV/AIDS patients who started antiretroviral treatment since 48 weeks of follow-up. Results The effectiveness rate of dolutegravir-based treatment was 85.1%. HIV/AIDS patients with a CD4 + count below 200 cel/mm3, singles, and HIV/AIDS patients whose treatment duration exceeded 12 months were at risk and likely to have an active infection (P = 0.0001). Conclusion Dolutegravir-based treatment remains effective among HIV/AIDS patients treated at the Nkembo Outpatient Treatment Center.

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