Harnessing nanomedicine for modulating microglial states in the central nervous system disorders: Challenges and opportunities

Haisong Li; Meng Guan; Ning-Ning Zhang; Yizhuo Wang; Tingting Liang; Haitao Wu; Chang Wang; Tianmeng Sun; Shuhan Liu

Biomedicine & Pharmacotherapy (Aug 2024)

Harnessing nanomedicine for modulating microglial states in the central nervous system disorders: Challenges and opportunities

Haisong Li,
Meng Guan,
Ning-Ning Zhang,
Yizhuo Wang,
Tingting Liang,
Haitao Wu,
Chang Wang,
Tianmeng Sun,
Shuhan Liu

Affiliations

Haisong Li: Cancer Center, The First Hospital, Jilin University, Changchun, Jilin, China; Department of Neurosurgery, The First Hospital, Jilin University, Changchun, Jilin, China
Meng Guan: Cancer Center, The First Hospital, Jilin University, Changchun, Jilin, China; Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital, Jilin University, Changchun, Jilin, China; National-local Joint Engineering Laboratory of Animal Models for Human Diseases, Changchun, Jilin, China
Ning-Ning Zhang: State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, Jilin, China
Yizhuo Wang: Cancer Center, The First Hospital, Jilin University, Changchun, Jilin, China
Tingting Liang: Cancer Center, The First Hospital, Jilin University, Changchun, Jilin, China
Haitao Wu: Cancer Center, The First Hospital, Jilin University, Changchun, Jilin, China
Chang Wang: Cancer Center, The First Hospital, Jilin University, Changchun, Jilin, China; Corresponding author.
Tianmeng Sun: Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital, Jilin University, Changchun, Jilin, China; National-local Joint Engineering Laboratory of Animal Models for Human Diseases, Changchun, Jilin, China; International Center of Future Science, Jilin University, Changchun, Jilin, China; State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, Jilin, China; Corresponding authors at: Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital, Jilin University, Changchun, Jilin, China.
Shuhan Liu: Cancer Center, The First Hospital, Jilin University, Changchun, Jilin, China; Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital, Jilin University, Changchun, Jilin, China; National-local Joint Engineering Laboratory of Animal Models for Human Diseases, Changchun, Jilin, China; Corresponding authors at: Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Immunology, The First Hospital, Jilin University, Changchun, Jilin, China.

Journal volume & issue: Vol. 177
p. 117011

Abstract

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Microglia are essential for maintaining homeostasis and responding to pathological events in the central nervous system (CNS). Their dynamic and multidimensional states in different environments are pivotal factors in various CNS disorders. However, therapeutic modulation of microglial states is challenging due to the intricate balance these cells maintain in the CNS environment and the blood–brain barrier’s restriction of drug delivery. Nanomedicine presents a promising avenue for addressing these challenges, offering a method for the targeted and efficient modulation of microglial states. This review covers the challenges faced in microglial therapeutic modulation and potential use of nanoparticle-based drug delivery systems. We provide an in-depth examination of nanoparticle applications for modulating microglial states in a range of CNS disorders, encompassing neurodegenerative and autoimmune diseases, infections, traumatic injuries, stroke, tumors, chronic pain, and psychiatric conditions. This review highlights the recent advancements and future prospects in nanomedicine for microglial modulation, paving the way for future research and clinical applications of therapeutic interventions in CNS disorders.

Published in Biomedicine & Pharmacotherapy

ISSN: 0753-3322 (Print); 1950-6007 (Online)
Publisher: Elsevier
Country of publisher: France
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.journals.elsevier.com/biomedicine-and-pharmacotherapy

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