Nature Communications (Aug 2022)

Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis

  • Laia Simó-Riudalbas,
  • Sandra Offner,
  • Evarist Planet,
  • Julien Duc,
  • Laurence Abrami,
  • Sagane Dind,
  • Alexandre Coudray,
  • Mairene Coto-Llerena,
  • Caner Ercan,
  • Salvatore Piscuoglio,
  • Claus Lindbjerg Andersen,
  • Jesper Bertram Bramsen,
  • Didier Trono

DOI
https://doi.org/10.1038/s41467-022-32649-7
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 17

Abstract

Read online

The treatment of colorectal cancer (CRC) is an unmet medical need in absence of early diagnosis. Here, the authors characterise cancer-specific transposable element-driven transpochimeric gene transcripts and highlight the role of POU5F1B in CRC growth and metastasis.