Endothelial cell dysfunction and targeted therapeutic drugs in sepsis
Kunwei Chen,
Dongdong Wang,
Minyue Qian,
Mengcao Weng,
Zhongteng Lu,
Kai Zhang,
Yue Jin
Affiliations
Kunwei Chen
Department of Anesthesiology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China
Dongdong Wang
Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Minyue Qian
Department of Anesthesiology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China
Mengcao Weng
Department of Anesthesiology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China
Zhongteng Lu
Children's Hospital, National Clinical Research Center for Child Health, Zhejiang University School of Medicine, Hangzhou, China
Kai Zhang
Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Corresponding author. Department of Anesthesiology, the First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qingchun Rd, Hangzhou, Zhejiang, 310003, China.
Yue Jin
Department of Anesthesiology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China; Children's Hospital, National Clinical Research Center for Child Health, Zhejiang University School of Medicine, Hangzhou, China; Corresponding author. Department of Anesthesiology, the Children's Hospital, Zhejiang University School of Medicine, 3333 Binsheng Rd, Hangzhou, Zhejiang, 310052, China.
Sepsis is a life-threatening organ dysfunction caused by an abnormal host response to microbial infections. During its pathogenesis, vascular endothelial cells (ECs) play a pivotal role as essential components in maintaining microcirculatory homeostasis. This article aims to comprehensively review the multifaceted physiological functions of vascular ECs, elucidate the alterations in their functionality throughout the course of sepsis, and explore recent advancements in research concerning sepsis-related therapeutic drugs targeting ECs.
