Nature Communications (Aug 2019)
Genomic landscape and chronological reconstruction of driver events in multiple myeloma
- Francesco Maura,
- Niccoló Bolli,
- Nicos Angelopoulos,
- Kevin J. Dawson,
- Daniel Leongamornlert,
- Inigo Martincorena,
- Thomas J. Mitchell,
- Anthony Fullam,
- Santiago Gonzalez,
- Raphael Szalat,
- Federico Abascal,
- Bernardo Rodriguez-Martin,
- Mehmet Kemal Samur,
- Dominik Glodzik,
- Marco Roncador,
- Mariateresa Fulciniti,
- Yu Tzu Tai,
- Stephane Minvielle,
- Florence Magrangeas,
- Philippe Moreau,
- Paolo Corradini,
- Kenneth C. Anderson,
- Jose M. C. Tubio,
- David C. Wedge,
- Moritz Gerstung,
- Hervé Avet-Loiseau,
- Nikhil Munshi,
- Peter J. Campbell
Affiliations
- Francesco Maura
- Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center
- Niccoló Bolli
- Department of Medical Oncology and Hemato-Oncology, University of Milan
- Nicos Angelopoulos
- The Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute
- Kevin J. Dawson
- The Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute
- Daniel Leongamornlert
- The Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute
- Inigo Martincorena
- The Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute
- Thomas J. Mitchell
- The Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute
- Anthony Fullam
- The Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute
- Santiago Gonzalez
- European Bioinformatics Institute, European Molecular Biology Laboratory (EMBL-EBI)
- Raphael Szalat
- Jerome Lipper Multiple Myeloma Center, Dana–Farber Cancer Institute, Harvard Medical School
- Federico Abascal
- The Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute
- Bernardo Rodriguez-Martin
- CIMUS - Molecular Medicine and Chronic Diseases Research Centre, University of Santiago de Compostela
- Mehmet Kemal Samur
- Jerome Lipper Multiple Myeloma Center, Dana–Farber Cancer Institute, Harvard Medical School
- Dominik Glodzik
- The Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute
- Marco Roncador
- The Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute
- Mariateresa Fulciniti
- Jerome Lipper Multiple Myeloma Center, Dana–Farber Cancer Institute, Harvard Medical School
- Yu Tzu Tai
- Jerome Lipper Multiple Myeloma Center, Dana–Farber Cancer Institute, Harvard Medical School
- Stephane Minvielle
- CRCINA, INSERM, CNRS, Université d’Angers, Université de Nantes
- Florence Magrangeas
- CRCINA, INSERM, CNRS, Université d’Angers, Université de Nantes
- Philippe Moreau
- CRCINA, INSERM, CNRS, Université d’Angers, Université de Nantes
- Paolo Corradini
- Department of Medical Oncology and Hemato-Oncology, University of Milan
- Kenneth C. Anderson
- Jerome Lipper Multiple Myeloma Center, Dana–Farber Cancer Institute, Harvard Medical School
- Jose M. C. Tubio
- The Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute
- David C. Wedge
- University of Oxford, Big Data Institute
- Moritz Gerstung
- European Bioinformatics Institute, European Molecular Biology Laboratory (EMBL-EBI)
- Hervé Avet-Loiseau
- IUC-Oncopole, and CRCT INSERM U1037
- Nikhil Munshi
- Jerome Lipper Multiple Myeloma Center, Dana–Farber Cancer Institute, Harvard Medical School
- Peter J. Campbell
- The Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute
- DOI
- https://doi.org/10.1038/s41467-019-11680-1
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
Multiple myeloma evolves continuously. Here the authors chronologically reconstruct driver events in multiple myeloma, noting a limited repertoire of initiating driver events that shape the evolutionary trajectory of the disease.
