Structural and functional analysis of human pannexin 2 channel

Zhihui He; Yonghui Zhao; Michael J. Rau; James A. J. Fitzpatrick; Rajan Sah; Hongzhen Hu; Peng Yuan

doi:10.1038/s41467-023-37413-z

Nature Communications (Mar 2023)

Structural and functional analysis of human pannexin 2 channel

Zhihui He,
Yonghui Zhao,
Michael J. Rau,
James A. J. Fitzpatrick,
Rajan Sah,
Hongzhen Hu,
Peng Yuan

Affiliations

Zhihui He: Department of Cell Biology and Physiology, Washington University School of Medicine
Yonghui Zhao: Department of Anesthesiology, Washington University School of Medicine
Michael J. Rau: Washington University Center for Cellular Imaging, Washington University School of Medicine
James A. J. Fitzpatrick: Department of Cell Biology and Physiology, Washington University School of Medicine
Rajan Sah: Center for the Investigation of Membrane Excitability Diseases, Washington University School of Medicine
Hongzhen Hu: Department of Anesthesiology, Washington University School of Medicine
Peng Yuan: Department of Cell Biology and Physiology, Washington University School of Medicine

DOI: https://doi.org/10.1038/s41467-023-37413-z
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 10

Abstract

Read online

The PANX2 channel is involved in skin homeostasis and neuronal development, but the molecular basis of channel function remains largely unknown. Here, the authors provide detailed analysis of the structure, function, and pharmacology of human PANX2.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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