Antibiotics (Dec 2022)

Impact of a Primary Care Antimicrobial Stewardship Program on Bacterial Resistance Control and Ecological Imprint in Urinary Tract Infections

  • Alfredo Jover-Sáenz,
  • María Ramírez-Hidalgo,
  • Alba Bellés Bellés,
  • Esther Ribes Murillo,
  • Meritxell Batlle Bosch,
  • José Cayado Cabanillas,
  • Sònia Garrido-Calvo,
  • María Isabel Gracia Vilas,
  • Laura Gros Navés,
  • María Jesús Javierre Caudevilla,
  • Alba Mari López,
  • Lidia Montull Navarro,
  • Mireia Ortiz Valls,
  • Gemma Terrer Manrique,
  • Pilar Vaqué Castilla,
  • José Javier Ichart Tomás,
  • Elena Justribó Sánchez,
  • Ester Andreu Mayor,
  • Joan Carrera Guiu,
  • Roser Martorell Solé,
  • Silvia Pallàs Satué,
  • Mireia Saura Codina,
  • Ana Vena Martínez,
  • José Manuel Albalat Samper,
  • Susana Cano Marrón,
  • Isabel Chacón Domínguez,
  • David de la Rica Escuin,
  • María José Estadella Servalls,
  • Ana M. Figueres Farreny,
  • Sonia Minguet Vidal,
  • Luís Miguel Montaña Esteban,
  • Josep Otal Bareche,
  • Mercè Pallerola Planes,
  • Francesc Pujol Aymerich,
  • Andrés Rodríguez Garrocho,
  • Antoni Solé Curcó,
  • Francisca Toribio Redondo,
  • María Cruz Urgelés Castillón,
  • Juan Valgañon Palacios,
  • Joan Torres-Puig-gros,
  • the P-ILEHRDA Group,
  • on behalf of Translational Research Group on Infectious Diseases of Lleida (Head Group, TRIDLE-IRBLleida)

DOI
https://doi.org/10.3390/antibiotics11121776
Journal volume & issue
Vol. 11, no. 12
p. 1776

Abstract

Read online

Antimicrobial stewardship programs (ASPs) are a central component in reducing the overprescription of unnecessary antibiotics, with multiple studies showing benefits in the reduction of bacterial resistance. Less commonly, ASPs have been performed in outpatient settings, but there is a lack of available data in these settings. We implemented an ASP in a large regional outpatient setting to assess its feasibility and effectiveness. Over a 5-year post-implementation period, compared to the pre-intervention period, a significant reduction in antibiotic prescription occurred, with a reduction in resistance in E. coli urinary isolates. ASP activities also were found to be cost-effective, with a reduction in medication prescription.

Keywords