Effect of Incorporation of Bioactive Agents in Dentin Bonding Agent on Bond Strength: A Systematic Review

Abstract

Background: This study analyzed how incorporating bioactive agents in dentin bonding agents affects bond strength. Methods: Full-text English articles were retrieved from PubMed, ScienceDirect, and Web of Science using MeSH terms and Boolean operators until July 2024. Studies from the last ten years were included and analyzed for bond strength changes. A total of 36 studies were reviewed, with 32 showing improved or stable bond strength, while four reported decreased strength. The modified CONSORT checklist for in vitro studies of dental materials was used to document the risk of bias. Results: Bioactive glass was the most common additive, used in ten studies. Micro-tensile bond strength was measured in 24 studies, while 12 assessed shear bond strength. Bioactive agents positively impacted bond strength, forming a stable resin-dentin interface. Discussion: Future research should focus on optimizing these products for improved clinical outcomes. The limited lifespan and marginal staining of dental composite restorations remain concerns for patients and clinicians. This systematic review seeks to provide an in-depth analysis of the impact of incorporating various bioactive agents into dentin bonding agents on the bond strength to dentin.

Keywords

• Dentin bonding agent, Dental adhesive, Shear Bond Strength, Micro Tensile Bond Strength, Bioactive Glasses, Bioactive Agents, Human Dentin, Bovine Dentin, Dentine