Macrophage-derived GPNMB trapped by fibrotic extracellular matrix promotes pulmonary fibrosis

Jing Wang; Xinxin Zhang; Min Long; Mengqin Yuan; Juan Yin; Wei Luo; Sha Wang; Yu Cai; Wei Jiang; Jie Chao

doi:10.1038/s42003-022-04333-5

Communications Biology (Feb 2023)

Macrophage-derived GPNMB trapped by fibrotic extracellular matrix promotes pulmonary fibrosis

Jing Wang,
Xinxin Zhang,
Min Long,
Mengqin Yuan,
Juan Yin,
Wei Luo,
Sha Wang,
Yu Cai,
Wei Jiang,
Jie Chao

Affiliations

Jing Wang: Jiangsu Provincial Key Laboratory of Critical Care Medicine, Zhongda Hospital, Department of Physiology, School of Medicine, Southeast University
Xinxin Zhang: Jiangsu Provincial Key Laboratory of Critical Care Medicine, Zhongda Hospital, Department of Physiology, School of Medicine, Southeast University
Min Long: Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics
Mengqin Yuan: Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics
Juan Yin: Jiangsu Provincial Key Laboratory of Critical Care Medicine, Zhongda Hospital, Department of Physiology, School of Medicine, Southeast University
Wei Luo: Jiangsu Provincial Key Laboratory of Critical Care Medicine, Zhongda Hospital, Department of Physiology, School of Medicine, Southeast University
Sha Wang: Jiangsu Provincial Key Laboratory of Critical Care Medicine, Zhongda Hospital, Department of Physiology, School of Medicine, Southeast University
Yu Cai: Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School of Southeast University
Wei Jiang: Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics
Jie Chao: Jiangsu Provincial Key Laboratory of Critical Care Medicine, Zhongda Hospital, Department of Physiology, School of Medicine, Southeast University

DOI: https://doi.org/10.1038/s42003-022-04333-5
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 15

Abstract

Read online

Macrophage-derived glycoprotein nonmetastatic melanoma protein B (GPNMB) is trapped by fibrotic extracellular matrix in a pulmonary fibrosis model and may activate resident normal fibroblasts, promoting fibrosis.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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