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Evaluation of CD4+CD25+ T lymphocyte response time kinetics in patients with chronic Chagas disease after in vitro stimulation with recombinant Trypanosoma cruzi antigens

Revista da Sociedade Brasileira de Medicina Tropical. 2013;(ahead):00-00


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Journal Title: Revista da Sociedade Brasileira de Medicina Tropical

ISSN: 0037-8682 (Print); 1678-9849 (Online)

Publisher: Sociedade Brasileira de Medicina Tropical (SBMT)

LCC Subject Category: Medicine: Internal medicine: Special situations and conditions: Arctic medicine. Tropical medicine

Country of publisher: Brazil

Language of fulltext: Portuguese, English, Spanish

Full-text formats available: PDF, HTML, XML



Suellen Carvalho de Moura Braz

Virginia Maria Barros de Lorena

Adriene Siqueira Melo

Maria da Glória Aureliano Melo Cavalcanti

Yara de Miranda Gomes


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Time From Submission to Publication: 8 weeks


Abstract | Full Text

Introduction CD4+CD25+ T lymphocytes have been implicated in the regulation of host inflammatory response against Trypanosoma cruzi, and may be involved in the clinical course of the disease. Methods Peripheral blood mononuclear cells from patients with chronic Chagas disease were cultured in the presence of T. cruzi recombinant antigens and assayed for lymphocytes at distinct time points. Results It was possible to differentiate clinical forms of chronic Chagas disease at days 3 and 5 according to presence of CD4+CD25+ T cells in cell cultures. Conclusions Longer periods of cell culture proved to be potentially valuable for prospective evaluations of CD4+CD25+ T lymphocytes in patients with chronic Chagas disease.