Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo

Huanzhen Ni; Marine Z. C. Hatit; Kun Zhao; David Loughrey; Melissa P. Lokugamage; Hannah E. Peck; Ada Del Cid; Abinaya Muralidharan; YongTae Kim; Philip J. Santangelo; James E. Dahlman

doi:10.1038/s41467-022-32281-5

Nature Communications (Aug 2022)

Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo

Huanzhen Ni,
Marine Z. C. Hatit,
Kun Zhao,
David Loughrey,
Melissa P. Lokugamage,
Hannah E. Peck,
Ada Del Cid,
Abinaya Muralidharan,
YongTae Kim,
Philip J. Santangelo,
James E. Dahlman

Affiliations

Huanzhen Ni: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology
Marine Z. C. Hatit: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology
Kun Zhao: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology
David Loughrey: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology
Melissa P. Lokugamage: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology
Hannah E. Peck: Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology
Ada Del Cid: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology
Abinaya Muralidharan: George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology
YongTae Kim: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology
Philip J. Santangelo: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology
James E. Dahlman: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology

DOI: https://doi.org/10.1038/s41467-022-32281-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 9

Abstract

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Next-generation lipid nanoparticles that target non-hepatocytes could be important clinical tools. Using in vivo DNA barcoding, the authors identify piperazine-containing lipids deliver mRNA to immune cells without targeting ligands.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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