Neutrophil Extracellular Traps in Digestive Cancers: Warrior or Accomplice

Yuxin Chen; Yuxin Chen; Lulu Han; Lulu Han; Lulu Han; Xiaoyan Qiu; Xiaoyan Qiu; Gang Wang; Gang Wang; Gang Wang; Junnian Zheng; Junnian Zheng

doi:10.3389/fonc.2021.766636

Frontiers in Oncology (Nov 2021)

Neutrophil Extracellular Traps in Digestive Cancers: Warrior or Accomplice

Yuxin Chen,
Yuxin Chen,
Lulu Han,
Lulu Han,
Lulu Han,
Xiaoyan Qiu,
Xiaoyan Qiu,
Gang Wang,
Gang Wang,
Gang Wang,
Junnian Zheng,
Junnian Zheng

Affiliations

Yuxin Chen: Cancer Institute, Xuzhou Medical University, Xuzhou, China
Yuxin Chen: Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, Xuzhou, China
Lulu Han: Cancer Institute, Xuzhou Medical University, Xuzhou, China
Lulu Han: Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, Xuzhou, China
Lulu Han: Center of Clinical Oncology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
Xiaoyan Qiu: Cancer Institute, Xuzhou Medical University, Xuzhou, China
Xiaoyan Qiu: Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, Xuzhou, China
Gang Wang: Cancer Institute, Xuzhou Medical University, Xuzhou, China
Gang Wang: Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, Xuzhou, China
Gang Wang: Center of Clinical Oncology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
Junnian Zheng: Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute, Xuzhou Medical University, Xuzhou, China
Junnian Zheng: Center of Clinical Oncology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China

DOI: https://doi.org/10.3389/fonc.2021.766636
Journal volume & issue: Vol. 11

Abstract

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Characterized as a complex of extracellular DNA fibers and granule proteins, neutrophil extracellular traps (NETs) are generated specifically by neutrophils which play a critical role in host defense and immune regulation. NETs have been initially found crucial for neutrophil anti-microbial function. Recent studies suggest that NETs are involved in tumorigenesis and cancer progression. However, the function of NETs in cancer remains unclear, which might be due to the variation of research models and the heterogeneity of cancers. Although most of malignant tumors have similar biological behaviors, significant differences indeed exist in various systems. Malignant tumors of the digestive system cause the most incidence and mortality of cancer worldwide. In this review, we would focus on research developments on NETs in digestive cancers to provide insights on their role in digestive cancer progression and future research directions.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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Abstract

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