JACC: Basic to Translational Science (Sep 2022)
Propionate Alleviates Abdominal Aortic Aneurysm by Modulating Colonic Regulatory T-Cell Expansion and Recirculation
- Fen Yang, MD,
- Ni Xia, MD, PhD,
- Shuang Guo, MD,
- Jiyu Zhang, MS,
- Yuhan Liao, MS,
- Tingting Tang, MD, PhD,
- Shaofang Nie, MD, PhD,
- Min Zhang, MD, PhD,
- Bingjie Lv, MD,
- Yuzhi Lu, MD, PhD,
- Jiao Jiao, MD, PhD,
- Jingyong Li, MD, PhD,
- Weimin Wang, PhD,
- Desheng Hu, MD, PhD,
- Xiang Cheng, MD, PhD
Affiliations
- Fen Yang, MD
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, and Key Laboratory of Biological Targeted Therapy of the Ministry of Education, Wuhan, China
- Ni Xia, MD, PhD
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, and Key Laboratory of Biological Targeted Therapy of the Ministry of Education, Wuhan, China
- Shuang Guo, MD
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, and Key Laboratory of Biological Targeted Therapy of the Ministry of Education, Wuhan, China
- Jiyu Zhang, MS
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, and Key Laboratory of Biological Targeted Therapy of the Ministry of Education, Wuhan, China
- Yuhan Liao, MS
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, and Key Laboratory of Biological Targeted Therapy of the Ministry of Education, Wuhan, China
- Tingting Tang, MD, PhD
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, and Key Laboratory of Biological Targeted Therapy of the Ministry of Education, Wuhan, China
- Shaofang Nie, MD, PhD
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, and Key Laboratory of Biological Targeted Therapy of the Ministry of Education, Wuhan, China
- Min Zhang, MD, PhD
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, and Key Laboratory of Biological Targeted Therapy of the Ministry of Education, Wuhan, China
- Bingjie Lv, MD
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, and Key Laboratory of Biological Targeted Therapy of the Ministry of Education, Wuhan, China
- Yuzhi Lu, MD, PhD
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, and Key Laboratory of Biological Targeted Therapy of the Ministry of Education, Wuhan, China
- Jiao Jiao, MD, PhD
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, and Key Laboratory of Biological Targeted Therapy of the Ministry of Education, Wuhan, China
- Jingyong Li, MD, PhD
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, and Key Laboratory of Biological Targeted Therapy of the Ministry of Education, Wuhan, China
- Weimin Wang, PhD
- Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Desheng Hu, MD, PhD
- Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Xiang Cheng, MD, PhD
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, and Key Laboratory of Biological Targeted Therapy of the Ministry of Education, Wuhan, China; Address for correspondence: Dr Xiang Cheng, Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, and Key Laboratory of Biological Targeted Therapy of the Ministry of Education. 1277 Jiefang Road, Jianghan District, Wuhan 430022, Hubei, China.
- Journal volume & issue
-
Vol. 7,
no. 9
pp. 934 – 947
Abstract
Summary: Emerging evidence supports that intestinal microbial metabolite short-chain fatty acids (SCFAs) increase the pool of regulatory T cells (Tregs) in the colonic lamina propria (cLP) and protect against nonintestinal inflammatory diseases, such as atherosclerosis and post-infarction myocardial inflammation. However, whether and how SCFAs protect the inflamed aortas of subjects with abdominal aortic aneurysm (AAA) remains unclear. Here, the authors revealed the protective effect of SCFAs on AAA in mice and the expansion of Tregs in the cLP, and propionate exerted Treg-dependent protection against AAA by promoting the recirculation of cLP-Tregs through colonic draining lymph nodes (dLNs) to the inflamed aorta.
