Current Oncology (Sep 2021)

Ampullary Carcinoma: An Overview of a Rare Entity and Discussion of Current and Future Therapeutic Challenges

  • Alessandro Rizzo,
  • Vincenzo Dadduzio,
  • Lucia Lombardi,
  • Angela Dalia Ricci,
  • Gennaro Gadaleta-Caldarola

DOI
https://doi.org/10.3390/curroncol28050293
Journal volume & issue
Vol. 28, no. 5
pp. 3393 – 3402

Abstract

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Ampullary carcinomas (ACs) represent a rare entity, accounting for approximately 0.2% of all gastrointestinal solid tumors and 20% of all periampullary cancers (PACs). Unfortunately, few data are available regarding the optimal therapeutic strategy for ACs due to their rarity, and physicians frequently encounter significant difficulties in the management of these malignancies. In this review, we will provide an overview of current evidence on AC, especially focusing on biological features, histological characteristics, and available data guiding present and future therapeutic strategies for these rare, and still barely known, tumors.

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