Development and Prospect of Intra-Articular Injection in the Treatment of Osteoarthritis: A Review

Abstract

Yin Zhang,1,2 Xinji Chen,1 Yu Tong,3 Junchao Luo,3 Qing Bi1,2 1Department of Orthopedic Surgery, Zhejiang Provincial People’s Hospital and People’s Hospital of Hangzhou Medical College, Hangzhou, Zhejiang 310014, People’s Republic of China; 2The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui 233004, People’s Republic of China; 3The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, People’s Republic of ChinaCorrespondence: Qing BiDepartment of Orthopedic Surgery, Zhejiang Provincial People’s Hospital, No. 158 Shangtang Road, Hangzhou, Zhejiang, People’s Republic of ChinaEmail [email protected]: Osteoarthritis (OA) is a common degenerative disease that affects the vast majority of the elderly and may eventually embark on the road of the total knee arthroplasty (TKA), although controversy still exists in the medical community about the best therapies for osteoarthritis. Compared with physical therapy, oral analgesics and other non-operative treatments, intra-articular injection is more safe and effective. Moreover, intra-articular injection is much less invasive and has fewer adverse reactions than surgical treatment. This article reviews mechanism, benefits and adverse reactions of corticosteroids (CS), hyaluronic acid (HA), platelet-rich plasma (PRP), mesenchymal stem cell (MSCs), stromal vascular fraction (SVF) and other new therapies (for example: gene therapy). The application prospect of intra-articular injection was analyzed according to the recent progress in drug research.Keywords: osteoarthritis, intra-articular injection, treatment, prospect, review

Keywords

• osteoarthritis
• intra-articular injection
• treatment
• prospect
• review