MicroRNAs in Hypertrophic, Arrhythmogenic and Dilated Cardiomyopathy

Abstract

MicroRNAs (miRNAs) are a class of non-coding RNAs of about 20 nucleotides in length, involved in the regulation of many biochemical pathways in the human body. The level of miRNAs in tissues and circulation can be deregulated because of altered pathophysiological mechanisms; thus, they can be employed as biomarkers for different pathological conditions, such as cardiac diseases. This review summarizes published findings of these molecular biomarkers in the three most common structural cardiomyopathies: human dilated, arrhythmogenic and hypertrophic cardiomyopathy.

Keywords

• microRNAs
• biomarkers
• inherited cardiomyopathies
• dilated cardiomyopathy
• arrhythmogenic cardiomyopathy
• hypertrophic cardiomyopathy