Calvarial Langerhans cell histiocytosis in an Adult: Typical imaging findings in an atypical age group

Amjad Samara, MD; Jordan Nepute, MD; Hsiang-Chih Lu, MD, PhD; Richard J. Perrin, MD, PhD; Rami W. Eldaya, MD, MBA

Radiology Case Reports (Dec 2019)

Calvarial Langerhans cell histiocytosis in an Adult: Typical imaging findings in an atypical age group

Amjad Samara, MD,
Jordan Nepute, MD,
Hsiang-Chih Lu, MD, PhD,
Richard J. Perrin, MD, PhD,
Rami W. Eldaya, MD, MBA

Affiliations

Amjad Samara, MD: Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA
Jordan Nepute, MD: Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA
Hsiang-Chih Lu, MD, PhD: Division of Neuropathology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
Richard J. Perrin, MD, PhD: Division of Neuropathology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA
Rami W. Eldaya, MD, MBA: Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Corresponding author.

Journal volume & issue: Vol. 14, no. 12
pp. 1478 – 1482

Abstract

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Langerhans Cell Histiocytosis (LCH) is a rare disorder characterized by neoplastic proliferation of Langerhans-type dendritic cells. LCH is most frequently encountered in the pediatric populations, and involvement of the skeletal system is a common manifestation. Herein, we report a case of LCH presented as an isolated skull lesion in a 66-year-old patient. This presentation has never been reported in the literature at this advanced age and suggests that, despite being exceptionally rare, clinicians should consider LCH in the differential diagnosis of skull lesions in the elderly with classical radiological appearance. Keywords: Langerhans Cell Histiocytosis, Skull lesion, Elderly patient

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiology-case-reports

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