International Journal of Endocrinology (Jan 2023)

Characteristics, Mortality, and Clinical Outcomes of Hospitalized Patients with COVID-19 and Diabetes: A Reference Single-Center Cohort Study from Poland

  • Michał Kania,
  • Konrad Mazur,
  • Michał Terlecki,
  • Bartłomiej Matejko,
  • Jerzy Hohendorff,
  • Zlata Chaykivska,
  • Mateusz Fiema,
  • Marianna Kopka,
  • Małgorzata Kostrzycka,
  • Magdalena Wilk,
  • Tomasz Klupa,
  • Przemysław Witek,
  • Barbara Katra,
  • Marek Klocek,
  • Marek Rajzer,
  • Maciej T. Malecki

DOI
https://doi.org/10.1155/2023/8700302
Journal volume & issue
Vol. 2023

Abstract

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Background. Diabetes is a risk factor for a severe course of COVID-19. We evaluated the characteristics and risk factors associated with undesirable outcomes in diabetic patients (DPs) hospitalized due to COVID-19. Materials and Methods. The data analysis of patients admitted between March 6, 2020, and May 31, 2021, to the University Hospital in Krakow (Poland), a reference center for COVID-19, was performed. The data were gathered from their medical records. Results. A total number of 5191 patients were included, of which 2348 (45.2%) were women. The patients were at the median age of 64 (IQR: 51–74) years, and 1364 (26.3%) were DPs. DPs, compared to nondiabetics, were older (median age: 70 years, IQR: 62–77 vs. 62, IQR: 47–72, and p 65 years, glycaemia >10 mmol/L, CRP and D-dimer level, prehospital insulin and loop diuretic use, presence of heart failure, and chronic kidney disease. Factors contributing to lower mortality were in-hospital use of statin, thiazide diuretic, and calcium channel blocker. Conclusion. In this large COVID-19 cohort, DPs constituted more than a quarter of hospitalized patients. The risk of death and other outcomes compared to nondiabetics was higher in this group. We identified a number of clinical, laboratory, and therapeutic variables associated with the risk of hospital death in DPs.